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activity adenine agents alkylation amonafide analogs anthracycline antibiotics antitumor assay AT-rich base pairs Bentham Science Publishers bisantrene Calicheamicin cancer cardiotoxicity catalytic domain cell lines Chem chromosome cleavage complex coli compounds covalent crystal structure cytotoxicity d(CGCGAATTCGCG)2 data measurement daunorubicin derivative diffraction distamycin DNA binding DNA cleavage DNA gyrase DNA topoisomerase dose doxorubicin drug design electron density ellipticine enzyme etoposide fibroblast collagenase flurbiprofen full length function gelatinase gene hemopexin-like domain HIV PR Hoechst hydrogen bonds interaction intercalate leukemia lexitropsin m-AMSA mammalian matrilysin matrix metalloproteinases Medicinal Chemistry mg/kg mice minor groove mitoxantrone MMP inhibitors molecule netropsin neutrophil collagenase nitrogen peptide phase position potency propeptide protein crystal structures protein crystallography protein structure recombinant region residues ring sialic acid stromelysin stromelysin 1 catalytic structure determination studies substituted substrate supercoiled therapeutic topoisomerase II topoisomerase II inhibition unit cell vitro vivo X-ray