Current Medicinal Chemistry |
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acid activation of PKC anti-tumor efficacy apoptosis assay ATP-binding ATP-competitive autophosphorylation Bentham Science Publishers bryostatin cancer carbonyl catalytic CDK inhibitors CDK2 CDKs cell lines cellular clinical complex compounds crystal structures cyclin cytokines diabetic disease domain dosing drug effects EGF-R kinase EGFr enzyme ERK2 expression FGF-R gene growth factor human hydrogen bond hydrophobic hydrophobic region induced inhibition interactions isozymes kinase activity kinase inhibitors ligand MAP kinase mediated membrane mg/kg molecule neuronal neurotrophins nitrogen observed olomoucine p38 inhibitors PDAC pharmacophore phosphorylation PKC activity PKC isozymes pocket potent preclinical proliferation prostatic carcinoma protein kinase purine purvalanol pyrazolopyrimidines pyridopyrimidines pyrrolopyrimidines quinazoline rats residues response ring role of PKC roscovitine selective inhibitors side chain signal transduction signal transduction pathways specific staurosporine studies substituents T-cells target therapeutic TNF-o treatment trkA tumor tyrosine kinase vivo xenografts