Current Medicinal Chemistry |
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acid adrenoreceptor amphotericin analogs androgen receptor antiandrogens antibiotic antifungal activity antifungal agents aryl aryl rings ATPase azoles bafilomycin A1 bafilomycin derivatives benign prostatic hyperplasia Bentham Science Publishers binding bioactivity biosynthesis broad spectrum butein Candida spp cell wall chalcones chicken osteoclast compounds concentrations Current cytotoxicity demonstrated dihydrotestosterone displayed drug design effect enzyme epoxide ergosterol evaluated figure finasteride fluconazole flucytosine flutamide fumigatus fungal fungal cell fungi human hydroxy hydroxy group increased infections inhibited inhibitors inhibitory activity interact isolated itraconazole jig/ml ketoconazole Licochalcone liver macrolide Medicinal Chemistry membrane methoxy methyl mg/kg moiety molecules mutagenic NADPH neoformans number of chalcones OH OH osteoclast oxidation pathway pg/ml pharmacological potent pradimicins properties protein proton reduced reductase SAR studies Sci-reductase selective showed sofalcone spectrum of activity sphingolipids steroid structure substituents subunit synthase synthesis tamsulosin target testosterone tissues toxicity tumour ug/ml V-ATPase various chalcones vitro activity vivo Voriconazole