Current Medicinal Chemistry |
Uobičajeni izrazi i fraze
administration agents alterations amino acids amphiphilic amphiphilic peptide animals anthracyclines antiparallel antitumor apoptosis attenuated B-sheets Bentham Science Publishers binding bioactive bisdioxopiperazines bleomycin blood breast cancer calibration line cardiac cardioprotective cardiotoxicity cells chelating CO2H complex compounds concentration conformationally constrained Cu2+ cumulative dose cyclic peptides cytotoxicity daunorubicin dexrazoxane doses of doxorubicin doxorubicin doxorubicin-induced drug EDTA effects of dexrazoxane enzymes epirubicin etoposide extended conformation factor Fe3+ folding formation g/dL given HbAo helical helix hemoglobin hemoglobin standards high doses HIV-1 protease HPLC hydrogen bonding hydrolysis hydrolysis of dexrazoxane hydrolysis products increased induced inhibition inhibitors interactions loops macrocycles metal ions mg/kg mg/mL mice mimetics mimic mitoxantrone mobile phase molecules myocardial lesions oxygen patients pretreatment with dexrazoxane protein protein surface mimetics rats razoxane receptor residues sequence short peptides shown side chains Sigma stabilise studies substrate Table TASP template tertiary structures topoisomerase total hemoglobin toxicity tumor turn