Current Medicinal Chemistry |
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4-hydroxycoumarin 4-hydroxypyrone Abstract active oxygen species Ametantrone 8a amino antibacterial activity antibiotics antioxidant antioxidant activity antitumor activity antiviral activity appropriate amines Bentham Science Publishers benzoyl peroxide bioisosteres biological activity Biological Evaluations bisphosphonates bone loss bone resorption C-3 substituent Cancer Res carbamate cell lines CH CH chemotypes chromophore cleaving clinical complexed coumarin cytotoxicity derivatives developed diaza DNA binding DNA cleavage doxorubicin Doxorubicin 1b drug design enantiomers enzyme estradiol estrogen exhibits flavonoids free radicals HIV protease hydrogen bond hydroperoxide hydroxyl radical inhibition inhibitor interaction isolated Krapcho lead structures leukemia LoVo LoVo/Dx mechanism mitoxantrone mitoxantrone 8b molecular molecule NF-KB nonpeptidic osteoclasts osteoporosis oxidative P388 murine leukemia peroxidic compounds phenolic Photo-Fenton Reagent potent protein radical scavengers reaction reactive redox residues ring Scheme side arms sponge steroidal studies substituted synthesis tannins template tetronic acid Thaisrivongs therapy toxicity treatment tumor vitro cytotoxicity vivo x-ray crystal structure