Current Medicinal Chemistry |
Uobičajeni izrazi i fraze
5’-monophosphate active site active site flap adduct adenine dinucleotide adenosine agents antileukemic apoptosis Azathioprine bacterial Bentham Science Publishers benzamide benzamide riboside bredinin cancer carboxamide carcinoma catalytic cell lines clinical CML-BC cofactor complex compounds concentration conformation covalent cytotoxicity dose drug E-XMP effect of MZR EICAR enzyme eukaryotic foetus IMPDH glucuronidation guanine guanine nucleotide hamster human IMPDH human type hydride transfer immunosuppressive IMP binding IMP dehydrogenase IMPDH activity IMPDH enzymes IMPDH inhibitors IMPDH reaction inhibit IMPDH inhibitor of IMPDH inosine interactions isoforms kinetic leukemia leukemic cells ligand lymphocytes mechanism metabolism mizoribine MMF 3 glday moiety monophosphate MPA binds mycophenolate mofetil mycophenolic acid MZR group N.1 cells NADH nicotinamide nucleoside observed OH OH pathway patients protein purine pyogenes renal transplantation residues ribavirin selenazofurin selenazole sequence specific studies substrate synthesis target therapy thiazole tiazofurin treatment Tritrichomonas foetus tumor cells type II IMPDH vitro vivo