Current Medicinal Chemistry |
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afford alcohol aldehyde alkyl alkyne amine analogs antibacterial activity antibiotics antihepatotoxic antitumor agents aryl B-lactams Bentham Science Publishers benzyl bile carbohydrate carboxylic acid CCl4-induced cephalosporins chiral imine chloride choleretic activity choleretic effect chronic cleavage colchicine component compound libraries condensation COOH Current Medicinal Chemistry cyclization cyclo cycloaddition cytotoxicity decreased derivatives disorders dose drug element of diversity enzyme esters exhibit hepatoprotective extract found effective galactosamine H H H hepatocytes hepatoprotective hepatoprotective activity hepatotoxicity hepatotoxins imine immobilized increased inhibition inhibitor of tubulin isocyanide isolated Keten liver liver damage liver injury Mannich Mannich reaction membrane metabolism methodology methoxy mg/kg mice microtubules multi-component reaction OCH3 OCHZO OH OH olefin Oral paracetamol penicillins protein quinolones rats reacted resin-bound ring serum SGOT SGPT showed potent silymarin solid-phase structural substituted subunit synthesis topo topoisomerase toxicity treatment trifluoroacetic acid tubulin tubulin polymerization Ugi reaction viral hepatitis vitro Wang resin yield