Current Medicinal Chemistry |
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082 receptors 2-arachidonoyl glycerol AAls Ag-THC amino acid aminoalkylindoles anandamide arachidonoyl aromatic behaves Bentham Science Publishers binding affinity binding assays binding sites cannabimimetic indoles cannabinoid agonists cannabinoid antagonists cannabinoid receptor cannabinoid receptor agonists cannabinoid receptor ligands CB1 receptors CHO cells classical cannabinoids compounds concentrations conformation cyclic AMP cyclic AMP production derivatives displacement efficacy endocannabinoid enzyme ethanolamide FAAH fatty acid amide G-protein glycerol GPCRs hCB1 in CHO helix high affinity Human CB1 hydrogen bond hydrolysis hydrophobic hydroxyl inactivation inactive indenes inhibition inhibitors interaction inverse agonist ligand Mechoulam methyl molecular molecule mutation n-pentyl nabilone neurones non-classical cannabinoids oleamide palmitoylethanolamide Pharmacol pharmacological pharmacophore phenolic phenolic hydroxyl potent produced protein rat brain RBL-2H3 cells recently receptor affinity reported ring selective side chain spleen steric structure studies substituent substrate suggested Table tissues traditional cannabinoids transfected vas deferens vitro vivo