Current Medicinal Chemistry |
Uobičajeni izrazi i fraze
active site Activity of PT523 affinity Alpha class GST amino acid amphetamine analogs of PT523 antifolates B-ring analogs Bentham Science Publishers Cancer carboxy carcinoma catalysis catalytic CDNB cell lines cellular chemokine complex compounds contours corpus striatum coworkers crystal structure cytotoxicity deprenyl deprenyl metabolites DHFR inhibitors domain dose DPP IV DPP IV inhibitors DPP IV-negative rats drug electrophilic enzyme folate Glutathione GSH analog GSH binding H-site helix hippocampus human hydrogen bond hydrolysed hydrophobic hydroxyl IC50 values inactivation inhibition interactions isoenzymes kcal/mol ligand metabolism mg/Kg mice molecule mutant N-terminal nonpolyglutamatable nordeprenyl Ortho peptide Pi class GSTs polyglutamation probe proline protein PT523 and MTX rat brain reaction receptor residues resistance role Rosowsky SCC VII sequence serine proteases shown side chain stabilisation substrate specificity synthesis Table therapeutic thiol thiolate tissue toxicity transfectants tumor Tyrg uptake vitro vivo YGlu