Current Medicinal Chemistry |
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2-position Adapted with permission amino acid arginine aromatic behavioral Bentham Science Publishers benztropine benztropine analogs binding affinity C-terminal C-terminal hexapeptide carboxyl Chem chemical shift CO2H cocaine cocaine analogs cocaine-like coli conformation COOH crystal structure cyclic pentapeptides D-Glu dipeptide dipeptide derivatives displayed dopamine transporter dopamine uptake inhibitors drug efficacious enzyme ETA/ETB receptor ETB receptor evaluated glutamate glycine glycine antagonists H Pg H heparin high affinity hydrogen bonding hydrophobic IC50 values inhibition inhibitory activity interaction kynurenic acid L1210 cell growth less potent ligand lipophilic mg/kg milacemide molecular molecule muscarinic receptors NCH3 NH2 Pg NMDA receptor NMDA receptor antagonists non-peptide P1 group peptide peptide backbone Pg F phenyl phenyl ring polyglutamation potent inhibitors protein receptor antagonists receptor binding receptor selective reported residues side chain structure-activity relationships substituents substituted synthesis therapeutic thrombin inhibitor tripeptide tropane trypsin vivo Y-linked