Current Medicinal Chemistry |
Uobičajeni izrazi i fraze
3H]NBMPR active compounds activity feature activity of LTA4 adducts analogs anticancer antileukemic antileukemic activity antimetabolite antineoplastic aryl aryl ring Bentham Science Publishers benzyl binding affinity bioactivity biochemical biosynthesis cancer carbon atom cellular chemical reactivity clinical compounds in series concentrations corresponding cyclic cysLT cytotoxic deamination dilazep dipyridamole drugs effects electronic enzyme epoxide hydrolase equilibrative NT erythrocytes ETMC evaluated function H OH OH hexobendine human erythrocytes ICso inactivation inactive increased inflammatory interaction ketones leukemia leukotriene lidoflazine ligands LTB4 LTC4 LTD4 mammalian Mannich bases Medicinal Chemistry melphalan mice mitochondria molecular molecules murine Na+-dependent NBMPR binding normal cells NT inhibitors NT inhibitory activity nucleoside transport inhibitors OCH3 peptidase peptidase activity peptide permeants potent NT prodrugs properties protein pteridine purine recently receptor antagonists reviewed screen shown specific structure substituent substrate synthesis Table therapeutic thiol tissue tumours unsaturated ketones values vitro vivo zileuton zinc-chelating